Penulis: Gregory Harris
Tanggal Nggawe: 11 April 2021
Tanggal Nganyari: 23 September 2024
Anonim
Pigeon Gene: Spread
Video: Pigeon Gene: Spread

Konten

Apa tes genetik BRAF?

Tes genetik BRAF nggoleki pangowahan, sing dikenal minangka mutasi, ing gen sing diarani BRAF. Gen minangka unit dhasar keturunan sing diwarisake saka ibu lan bapak sampeyan.

Gen BRAF nggawe protein sing mbantu ngontrol pertumbuhan sel. Dikenal minangka oncogene. Oncogene bisa digunakake kaya pedal gas ing mobil. Biasane, oncogene nguripake pertumbuhan sel kaya sing dibutuhake. Nanging yen sampeyan duwe mutasi BRAF, kaya pedal gas sing macet, lan gen ora bisa nyegah sel tuwuh saya gedhe. Wutah sel sing ora bisa dikendhaleni bisa nyebabake kanker.

Mutasi BRAF bisa diwarisake saka wong tuwa utawa entuk umur mengko. Mutasi sing kedadeyan mengko ing umure biasane disebabake dening lingkungan utawa saka kesalahan sing kedadeyan ing awak nalika divisi sel. Mutasi BRAF sing diwarisake arang banget, nanging bisa nyebabake masalah kesehatan sing serius.

Mutasi BRAF sing dipikolehi (uga dikenal minangka somatik) luwih umum. Mutasi iki ditemokake ing udakara setengah saka kabeh kasus melanoma, bentuk kanker kulit sing paling serius. Mutasi BRAF uga asring ditemokake ing kelainan liyane lan macem-macem jinis kanker, kalebu kanker usus, tiroid, lan ovarium. Kanker kanthi mutasi BRAF cenderung luwih serius tinimbang sing ora duwe mutasi.


Jeneng liya: Analisis mutasi gen BRAF, Melanoma, mutasi BRAF V600, kobra

Digunakake kanggo apa?

Tes kasebut paling asring digunakake kanggo nggoleki mutasi BRAF ing pasien karo melanoma utawa kanker sing gegandhengan karo BRAF liyane. Obat kanker tartamtu efektif banget ing wong sing duwe mutasi BRAF. Obat sing padha ora efektif lan kadang mbebayani kanggo wong sing ora duwe mutasi.

Tes BRAF uga bisa digunakake kanggo ngerti yen sampeyan duwe risiko kanker adhedhasar riwayat kulawarga lan / utawa riwayat kesehatan sampeyan dhewe.

Napa aku butuh tes genetik BRAF?

Sampeyan bisa uga kudu tes BRAF yen sampeyan wis didiagnosis melanoma utawa jinis kanker liyane. Ngerti manawa sampeyan duwe mutasi bisa mbantu panyedhiya resep perawatan sing bener.

Sampeyan uga kudu mbutuhake tes iki kanggo ndeleng manawa sampeyan duwe risiko luwih ngalami kanker. Faktor risiko kalebu riwayat kulawarga kanker lan / utawa ngalami kanker nalika isih cilik. Umur tartamtu gumantung karo jinis kanker.


Apa sing kedadeyan sajrone tes genetik BRAF?

Umume tes BRAF ditindakake kanthi prosedur sing diarani biopsi tumor. Sajrone biopsi, panyedhiya perawatan kesehatan bakal njupuk sepotong jaringan kanthi ngethok utawa nggosok lumahing tumor. Yen panyedhiya sampeyan kudu nyoba jaringan tumor saka njero awak, dheweke bisa nggunakake jarum khusus kanggo narik sampel kasebut.

Apa aku kudu nindakake apa-apa kanggo nyiapake tes?

Sampeyan biasane ora butuh persiapan khusus kanggo tes BRAF.

Apa ana risiko kanggo tes kasebut?

Sampeyan bisa uga nandhang bruising utawa getihen ing situs biopsi. Sampeyan uga bisa uga duwe rasa ora nyaman ing situs kasebut suwene rong dina.

Apa tegese asile?

Yen sampeyan ngalami melanoma utawa jinis kanker liyane, lan asile nuduhake sampeyan duwe mutasi BRAF, panyedhiya bisa menehi resep obat sing dirancang kanggo target mutasi kasebut. Obat-obatan kasebut bisa luwih efektif tinimbang perawatan liyane.

Yen sampeyan ngalami melanoma utawa jinis kanker liyane, lan asil kasebut nuduhake sampeyan aja duwe mutasi, panyedhiya bakal menehi macem-macem jinis obat kanggo ngobati kanker.


Yen sampeyan durung didiagnosis ngalami kanker lan asile nuduhake sampeyan duwe mutasi genetik BRAF ora tegese sampeyan duwe kanker, nanging sampeyan duwe risiko kanker sing luwih dhuwur. Nanging pemeriksaan kanker sing luwih asring, kayata ujian kulit, bisa nyuda resiko sampeyan. Sajrone ujian kulit, panyedhiya perawatan kesehatan bakal mriksa kulit ing kabeh awak kanthi tliti kanggo mriksa mol lan tuwuh curiga liyane.

Ngomong karo panyedhiya babagan langkah-langkah liyane sing bisa ditindakake kanggo nyuda resiko.

Sinau luwih lengkap babagan tes laboratorium, rentang referensi, lan asil pangerten.

Apa ana liyane sing kudu aku ngerteni babagan tes BRAF?

Sampeyan bisa uga ngrungokake panyedhiya sampeyan babagan mutasi V600E. Ana macem-macem jinis mutasi BRAF. V600E minangka jinis mutasi BRAF sing paling umum.

Referensi

  1. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc. c2018. Kanker Kulit Melanoma; [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.cancer.org/cancer/melanoma-skin-cancer.html
  2. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc. c2018. Gen oncogenes lan suppressor tumor; [dianyari 2014 25 Jun; dikutip 2018 Jul 10]; [udakara 4 layar]. Kasedhiya saka: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-suppressor-genes.html
  3. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc. c2018. Terapi sing Disasarake kanggo Kanker Kulit Melanoma; [dianyari 2018 28 Jun; dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.cancer.org/cancer/melanoma-skin-cancer/treating/targeted-therapy.html
  4. Kanker.Net [Internet]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Tes Genetik kanggo Risiko Kanker; 2017 Jul [dikutip 2018 Jul 10]; [udakara 4 layar]. Kasedhiya saka: https://www.cancer.net/navigating-cancer-care/cancer-basics/genetics/genetic-testing-cancer-risk
  5. Kanker.Net [Internet]. Alexandria (VA): American Society of Clinical Oncology; c2005–2018. Ngerti Terapi sing Diangkah; 2018 Mei [dikutip 2018 Jul 10]; [udakara 4 layar]. Kasedhiya saka: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/ Understanding-targeted-therapy
  6. Onkologi Integrasi [Internet]. Perusahaan Laboratorium Amerika; c2018. Analisis Mutasi Gene BRAF; [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.integratedoncology.com/test-menu/braf-gene-mutation-analysis/07d322d7-33e3-480f-b900-1b3fd2b45f28
  7. Tes Lab Online [Internet]. Washington D.C: Asosiasi Amerika kanggo Kimia Klinis; c2001–2018. Biopsi; [dianyari 2017 10 Jul; dikutip 2018 Jul 10]; [udakara 2 layar]. Kasedhiya saka: https://labtestsonline.org/glossary/biopsy
  8. Tes Lab Online [Internet]. Washington D.C .: Asosiasi Amerika kanggo Kimia Klinis; c2001–2018. Tes Genetik kanggo Terapi Kanker sing Diangkah; [dianyari 2018 10 Jul; dikutip 2018 Jul 10]; [udakara 2 layar]. Kasedhiya saka: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
  9. Klinik Mayo: Laboratorium Medis Mayo [Internet]. Yayasan Mayo kanggo Pendidikan lan Riset Kedokteran; c1995–2018. ID Tes: BRAFT: Analisis Mutasi BRAF (V600E), Tumor: Klinis lan Interpretif; [dikutip 2018 Jul 10]; [udakara 4 layar]. Kasedhiya saka: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35370
  10. Institut Kanker Nasional [Internet]. Bethesda (MD): Departemen Kesehatan lan Layanan Manungsa A.S. Tes Genetik kanggo Sindrom Kanker Keturunan; [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
  11. Institut Kanker Nasional [Internet]. Bethesda (MD): Departemen Kesehatan lan Layanan Manungsa A.S. Kamus Istilah Kanker NCI: Gen BRAF; [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-gene
  12. Institut Kanker Nasional [Internet]. Bethesda (MD): Departemen Kesehatan lan Layanan Manungsa A.S. Kamus Istilah Kanker NCI: Mutasi BRAF (V600E); [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/braf-v600e-mutation
  13. Institut Kanker Nasional [Internet]. Bethesda (MD): Departemen Kesehatan lan Layanan Manungsa A.S. Kamus Istilah Kanker NCI: gen; [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
  14. Institut Kanker Nasional [Internet]. Bethesda (MD): Departemen Kesehatan lan Layanan Manungsa A.S. Kamus Istilah Kanker NCI: oncogene; [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oncogene
  15. Perpustakaan Kedokteran Nasional A.S. NIH: Referensi Omah Genetika [Internet]. Bethesda (MD): Departemen Kesehatan lan Layanan Manungsa A.S. Gen BRAF; 2018 Jul 3 [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://ghr.nlm.nih.gov/gene/BRAF
  16. Perpustakaan Kedokteran Nasional A.S. NIH: Referensi Omah Genetika [Internet]. Bethesda (MD): Departemen Kesehatan lan Layanan Manungsa A.S. Apa sing diarani mutasi gen lan kepiye cara mutasi ?; 2018 Jul 3 [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://ghr.nlm.nih.gov/primer/mutationsanddisorder/genemutation
  17. Diagnostik Quest [Internet]. Diagnostik Quest; c2000–2017. Pusat Tes: Melanoma, Mutasi BRAF V600, Cobas: Pandhuan Interpretif; [dikutip 2018 Jul 10]; [udakara 4 layar]. Kasedhiya saka: https://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_BRAF_V600&tabview
  18. Diagnostik Quest [Internet]. Diagnostik Quest; c2000–2017. Pusat Tes: Melanoma, Mutasi BRAF V600, Cobas: Ringkesan; [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=90956
  19. Pusat Kesehatan Universitas Rochester [Internet]. Rochester (NY): Pusat Kesehatan Universitas Rochester; c2018. Ensiklopedia Kesehatan: Melanoma: Terapi Target; [dikutip 2018 Jul 10]; [udakara 2 layar]. Kasedhiya saka: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=34&contentid=BMelT14
  20. UW Health [Internet]. Madison (WI): Otoritas Rumah Sakit lan Klinik Universitas Wisconsin; c2018. Informasi Kesehatan: Ujian Fisik Kulit kanggo Kanker Kulit: Ikhtisar Ujian; [dianyari 2017 3 Mei; dikutip 2018 Jul 18]; [udakara 2 layar]. Kasedhiya saka: https://www.uwhealth.org/health/topic/testdetail/physical-exam/hw206422.html#hw206425UW
  21. Kesehatan [Internet]. Madison (WI): Otoritas Rumah Sakit lan Klinik Universitas Wisconsin; c2018. Informasi Kesehatan: Kanker Kulit, Melanoma: Ringkesan Topik; [dianyari 2017 3 Mei; dikutip 2018 Jul 10]; [udakara 2 layar]. Kasedhiya saka: https://www.uwhealth.org/health/topic/major/skin-cancer-melanoma/hw206547.html
  22. Kesehatan UW: Rumah Sakit Anak Kulawarga Amerika [Internet]. Madison (WI): Otoritas Rumah Sakit lan Klinik Universitas Wisconsin; c2018. Kesehatan Anak: Biopsi; [dikutip 2018 Jul 10]; [udakara 3 layar]. Kasedhiya saka: https://www.uwhealthkids.org/kidshealth/en/mother/biopsy.html/
  23. Zial J, Hui P. Tes mutasi BRAF ing praktik klinis. Pakar Rev Mol Diagn [Internet]. 2012 Mar [dikutip 2018 Jul 10]; 12 (2): 127–38. Kasedhiya saka: https://www.ncbi.nlm.nih.gov/pubmed/22369373

Informasi ing situs iki ora digunakake minangka sulih kanggo perawatan medis utawa saran profesional. Hubungi panyedhiya layanan kesehatan yen sampeyan duwe pitakon babagan kesehatan.

Artikel Saka Portal

Kelenjar adrenal
Obat

Kelenjar adrenal

Kelenjar adrenal yaiku rong kelenjar bentuk egi telu cilik. iji kelenjar ditemokake ing i ih ndhuwur ginjel. aben kelenjar adrenal ukurane ing i ih ndhuwur jempol. i ih njaba kelenjar diarani kortek ....
Tes metanol
Obat

Tes metanol

Methanol minangka zat ing bi a kedadeyan kanthi alami kanthi jumlah ithik ing awak. umber utama metanol ing awak kalebu woh-wohan, ayuran, lan ombenan diet ing ngemot a partam.Methanol minangka jini a...